Covid Vaccines: Cardiac Damage by LNPs, mRNA and Spike Protein

by Dr. William Makis, Global Research:

Papers reviewed

• Oct. 12, 2023 – Schreckenberg et al – Cardiac side effects of RNA-based SARS-CoV-2 vaccines: Hidden cardiotoxic effects of mRNA-1273 and BNT162b2 on ventricular myocyte function and structure
• Sep. 19, 2023 – Nakahara et al – Assessment of Myocardial ¹⁸F-FDG Uptake at PET/CT in Asymptomatic SARS-CoV-2–vaccinated and Nonvaccinated Patients
• Aug. 17, 2023 – Parry et al – ‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA
• May 5, 2023 – Barmada et al – Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine–associated myocarditis

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Oct. 12, 2023 – Schreckenberg et al – Cardiac side effects of RNA-based SARS-CoV-2 vaccines: Hidden cardiotoxic effects of mRNA-1273 and BNT162b2 on ventricular myocyte function and structure

• Germany/Hungary study
• studied Pfizer & Moderna COVID-19 mRNA jab effects on adult rat heart cells
• at 24 hours, heart cells looked and functioned normally (Pfizer and Moderna)
• at 48 hours, Moderna treated heart cells had arrhythmic, irregular, partially peristaltic contracting myocytes
• at 72 hours, Moderna treated heart cells almost completely stopped functioning
• at 48 hours, Pfizer treated heart cells contracted rhythmically and uniformly, but showed increase in cell shortening, contraction velocity, relaxation velocity
• at 72 hours, Pfizer treated heart cells, only 27% contract normally.
• mRNA detected all over the heart, taken up by heart cells but also non-heart cells like endothelial cells and fibroblasts (more mRNA uptake than heart cells).
• spike protein was detected at 48 hours for Pfizer and Moderna
• Discussion:
  • Pfizer and Moderna mRNA sequences are different, LNPs are different.
  • LNP-mRNA didn’t damage heart cells in this study, but not possible to make any conclusions as LNP controls are not available to study
  • enough spike protein must be translated to cause heart cell damage by both Pfizer and Moderna
  • Pfizer and Moderna cause abnormalities in heart cell function but through different mechanisms
    • Moderna causes dysfunction of calcium channels leading to arrhythmic and irregular contractions
    • Pfizer messes with PKA (protein Kinase A), causes sustained PKA activation, stimulation of beta-adrenergic signaling – increased heart rate
    • Increasing Pfizer dose 3x doesn’t give Moderna effects at all.
  • Both Pfizer and Moderna mechanisms are risk factors for sudden cardiac death, ventricular tachyarrhythmias and contractile dysfunction.
  • Both Pfizer and Moderna cause cardiomyopathy, which is clinically diagnosed as myocarditis or pericarditis.

Sep. 19, 2023 – Nakahara et al – Assessment of Myocardial ¹⁸F-FDG Uptake at PET/CT in Asymptomatic SARS-CoV-2–vaccinated and Nonvaccinated Patients

• Japanese retrospective study looked at imaging vaccinated and unvaccinated patients with radioactively labeled sugar (FDG) and PET/CT (normally used to diagnose cancer or inflammatory diseases)
• Vaccinated patients had higher FDG uptake than unvaccinated for up to 6 months after their 2nd mRNA dose, but not longer than 6 months.
• Pfizer patients had similar uptake to Moderna patients
• Abnormal uptake in lymph nodes was seen up to 4 months
• Conclusions:
  • Pfizer and Moderna cause heart inflammation that can last up to 6 months after last dose (although this is not the ideal imaging test for this)
  • Pfizer and Moderna cause a similar degree of heart inflammation
  • Pfizer and Moderna also cause inflammation in the lymph nodes on the injected side for up to 4 months

Aug. 17, 2023 – Parry et al – ‘Spikeopathy’: COVID-19 Spike Protein Is Pathogenic, from Both Virus and Vaccine mRNA

• SARS-CoV-2 spike protein is pathogenic, whether from the virus, mRNA or adenovectorDNA vaccines.
• Biodistribution rodent study data show lipid nanoparticles carry mRNA to all organs and cross blood-brain and blood-placenta barriers. Some of these tissues are likely to be impervious to viral infection; therefore, the biohazard is particularly from vaccination.
• Lipid-nanoparticles have inflammatory properties.
• Modification of mRNA with N1-methylpseudouridine for increased stability leads to the production of spike proteins for months. It is uncertain how many cells and from which organs mRNA spike proteins are produced, and therefore, the exact effective dose delivered per vaccine vial is unknown.
• Long-term fate of mRNA within cells is currently unknown.
• mRNA and adenovector DNA vaccines act as ‘synthetic viruses’.
• In the young and healthy, and even in many older individuals with vulnerable comorbidities, the encoding-based COVID-19 vaccines will likely transfect a far more diverse set of tissues than infection by the virus itself.
• Evidence suggests reverse transcription of mRNA into a DNA copy is possible. This further suggests the possibility of intergenerational transmission if germline cells incorporate the DNA copy into the host genome.
• Production of foreign proteins such as spike protein on cell surfaces can induce autoimmune responses and tissue damage. This has profoundly negative implications for any future mRNA-based drug or vaccine.
• Spike protein exerts its pathophysiological effects (‘spikeopathy’) via several mechanisms that lead to inflammation, thrombogenesis, and endotheliitis-related tissue damage and prion-related dysregulation.
• Interaction of the vaccine-encoded spike protein with ACE-2, P53 and BRCA1 suggests a wide range of possible biological interference with oncological potential.
• Adverse event data from official pharmacovigilance databases, an FDA-Pfizer report obtained via FOI, show high rates and multiple organ systems affected: primarily neurological, cardiovascular, and reproductive.
• Pfizer and Moderna mRNA COVID-19 vaccines’ clinical trial data independently interpreted has been peer-review and published to show an unfavourable risk/benefit, especially in the non-elderly. The risks for children clearly outweigh the benefits.
• Repeated COVID-19 vaccine booster doses appear to induce tolerance and may contribute to recurrent COVID-19 infection and ‘long COVID’.
• Treatment modalities for ‘spikeopathy’-related pathology in many organ systems, require urgent research and provision to millions of sufferers of long-term COVID-19 vaccine injuries.

Gene-based technologies:

• unprecedented number of adverse events appears to be associated with the spike proteins produced by the gene-based technologies employed by Pfizer, Moderna, AstraZeneca, J&J
• Non-western countries use small quantities of gene-based vaccines: Sputnik V and EpiVacCorona COVID-19 vaccines in Russia, iNCOVACC in India, and Convidecia in China – but majority are traditional protein-based or inactivated virus non-genetic vaccines.
• mRNA never used before (only in experimental settings, to treat metastatic cancer)
• viral-vectorDNA vaccines had limited use in Ebola, Dengue, Japanese encephalitis
• Operation Warp Speed / Department of Defense – many safety testing and toxicology protocols were bypassed to get Emergency Use Authorization status.
• Pfizer biodistribution study (42 rats injected with 50ug mRNA, 21 rates 100 ug)
  • by 48hr, 75% of the injection left the injection site for elsewhere
  • LNPs go mostly to liver & spleen, but also everywhere else
  • small mRNA quantities in liver & lymph nodes can produce high levels of spike protein – can’t predict spike production
• mRNA found in blood plasma at 28 days, in lymph nodes at 60 days after jab.
• LNP-mRNA complexes are around 100nm in size, should be processed by liver but they’re bound by macrophages (Kupffer cells) which slows down their processing
• Pfizer & Moderna LNPs are significantly inflammatory on their own
• Novavax has spike proteins bound to a lipid nanoparticle – can cause myocarditis (the nanoparticle itself could be causing the myocarditis)
• Astrazeneca vector DNA also found distantly (bone marrow, liver, spleen, lung)
• AstraZeneca spike protein has been found in clots and brain vessel walls

Traditional Vaccines in India and China Not Causing High Number of Adverse Events:

• Traditional vaccines: inactivated virus vaccine technologies such as Covaxin manufactured by Bharat Biotech in India, and CoronaVac made by Sinovac in China
• also traditional recombinant protein-based COVID-19 vaccines such as Spikogen, jointly developed by Australian and Iranian-based companies
• Traditional COVID-19 vaccines have not produced the high rates of adverse event reports that characterize the gene-based COVID-19 vaccines.
• This is further evidence that the risk is in the body-wide biodistribution and prolonged production of spike proteins.
• It points to pathogenicity of the spike protein and, given the evidence described above, also the lipid-nanoparticle carrier matrix.

Autoimmune Risk of Foreign Antigens Presented by the Body’s Own Cells

• spike protein is innately toxic
• even if it wasn’t toxic, it is still foreign and could produce autoimmune damage
• LNP delivers mRNA to all organs
• expression of spike on cell surfaces and as a soluble protein within organs and blood stream induces T-cell destruction of cells, and B-cell antibodies that can cause immune complex deposition further damaging tissues

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