by Brenda Baletti, Ph.D., Childrens Health Defense:
A new study from Iran found that two rare birth defects — atrioventricular septal defects and cleft palate — occurred more often in infants whose mothers received an aluminum-containing COVID-19 vaccine during the first 12 weeks of pregnancy compared with mothers who received the vaccine later or not at all.
A new study from Iran found that two rare birth defects — atrioventricular septal defects (AVSD) and cleft palate — occurred more often in infants whose mothers received a COVID-19 vaccine during the first 12 weeks of pregnancy compared with mothers who received the vaccine later or not at all.
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Unlike studies conducted in the U.S. and Europe, none of the women in the Iranian study received mRNA vaccines — however, all of the COVID-19 vaccines available in Iran contain 0.25-0.50 milligrams of aluminum adjuvant, Children’s Health Defense Senior Research Scientist Karl Jablonowski told The Defender.
Shots containing aluminum are not typically recommended for pregnant women in their first trimester, Jablonowski said.
Participants in the new study received either inactivated-virus or viral-vector COVID-19 vaccines. Researchers anonymized the specific vaccine brands “due to ethical and regulatory constraints.”
Other Iranian studies indicate that China’s Covilo, also known as Sinopharm, is the most commonly administered COVID-19 vaccine in Iran. That shot, Coviran Barkat, and the India-produced Covaxin were available in Iran at the time of the study.
The study, published last month in Sage Open Medicine, analyzed 1,352 pregnancies from two Iranian cities between 2022 and 2023.
Researchers compared three groups: 303 women who received no COVID-19 vaccine during pregnancy, 262 women who received at least one dose between conception and 11 weeks, 6 days of gestation — the window when fetal organs form — and 787 women vaccinated after the first trimester.
The authors said they were motivated by a gap in the research: COVID-19 vaccination is widely recommended for pregnant women worldwide, yet few studies have examined the link between early-pregnancy vaccination and birth defects.
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