by Steve Watson, Modernity News:
In a development straight out of science fiction, a Connecticut-based startup called Bexorg is using technology to maintain functioning human brains outside the body for extended periods.
These disembodied organs, sourced from recently deceased donors, are being employed to test experimental drugs aimed at neurodegenerative diseases.
The work has ignited fresh debate: could these brains possess some form of consciousness?
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Not alive, but not dead: disembodied human brains used for drug testing. By restoring some functions to intact brains from deceased donors, the startup Bexorg hopes to create a better drug development test bed for neurodegenerative diseases Science https://t.co/137NSt8g6K
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The company’s BrainEx system pumps synthetic blood through the brain’s vascular network, delivering oxygen and nutrients while maintaining appropriate temperature and conditions.
This allows the brains to remain metabolically active for up to 24 hours or more, providing a realistic platform for observing how drugs interact with human neural tissue at a cellular and molecular level.
Unlike traditional animal testing or lab-grown organoids, these intact human brains carry decades of real-world exposure to medications, environmental factors, and aging processes.
Bexorg founder Zvonimir Vrselja has emphasized the advantage: cells that have existed for 60 to 80 years offer insights far beyond simplified models.
The Science report notes that this approach has already yielded practical results. Pharmaceutical firm Biohaven used data from Bexorg’s brains to advance a drug targeting energy deficits in diseased brains. In one case, a Parkinson’s treatment that failed in mice showed promise at much lower doses in the human brains.
