Just like they went after one of the very best cures for PSYOP-19 in Ivermectin…
…while the anti-cancer properties of Hydroxychloroquine were mentioned in passing, a pair of studies that Dr. Makis recently cited have inspired this Substack to revise the ‘New and Improved Joe Tippens Protocol’ at the end of this article such that we may now have an even more comprehensive cancer cure; to wit:
NEW ARTICLE: HYDROXYCHLOROQUINE and LUNG CANCER – Two studies show fascinating mechanisms of ANTI-CANCER action!
Papers Reviewed: 2019 Malhotra et al: “Phase Ib/II study of hydroxychloroquine in combination with chemotherapy in patients with metastatic non-small cell lung cancer (NSCLC)”
2018 Li et al: “Hydroxychloroquine induced lung cancer suppression by enhancing chemo-sensitization and promoting the transition of M2-TAMs to M1-like macrophages”
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The 2019 Malhotra paper talks about hydroxychloroquine as a cancer cell autophagy inhibitor to inhibit lung tumor progression:
“Preclinical studies in engineered mouse lung cancer models show that KRAS mutant lung tumors depend on autophagy, and inhibition of autophagy inhibits tumor development and progression.”
Results:
“The addition of hydroxychloroquine to chemotherapy was safe and resulted in modest improvement in response rate for select subgroup of patients with newly diagnosed metastatic NSCLC (KRAS-mutated tumors).”
“We also established that 200 mg BID of hydroxychloroquine in combination with chemotherapy is safe and tolerable”
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The 2018 Li paper discusses two important effects of Hydroxychloroquine on Lung Cancer:
1. HCQ enhances the sensitivity of lung cancer cells to chemotherapeutic drugs
HCQ functions as a chemo-sensitizer to enhance the anticancer effects of chemotherapeutic agents without killing cancer cells directly
HCQ reverses drug sequestration in lysosomes by increasing the lysosomal pH to inactivate P-gp
2. HCQ also exerts anti-tumor effect via immune microenvironment at tumor site
HCQ markedly decreased tumour weight in immunocompetent C57BL/6 J mice but did not show any influence in CD8+ T cell-depleted mice
HCQ induces CD8+ T cell-based tumour suppression via macrophages
HCQ induces the transition of M2-TAMs to M1-like macrophages
“results indicate that HCQ switches M2-TAMs into M1-like macrophages to enhance CD8+ T cell immunity”
“In summary, the data presented in this study clearly showed that by increasing the lysosomal pH in cancer cells and fostering the transition of M2-TAMs to M1 macrophages to induce CD8+ T cell anti-tumour effects, HCQ could function as a chemo-sensitizer and immune regulator to enhance the therapeutic effects of NSCLC.”
“HCQ is a promising agent for cancer treatment to improve the quality of life of NSCLC patients.”
It’s that interesting? 🤔
Maybe there was more to the attacks on HYDROXYCHLOROQUINE than just COVID-19 (!!)
Just like there are high quality research studies showing that Ivermectin enhances the efficacy of chemotherapy, we now have irrefutable evidence that Hydroxychloroquine also greatly improves chemotherapy outcomes.
