NIH-Funded Researchers Engineer Drug-Resistant Bat-Human Hybrid Influenza Viruses in Missouri

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by Jon Fleetwood, Modernity News:

A new peer-reviewed study confirms that U.S. National Institutes of Health (NIH)–funded scientists have genetically engineered bat-human hybrid influenza viruses using reverse genetics in Missouri.

These purported viruses are resistant to common antivirals, capable of replicating in mammalian cells, and deliberately mutated for drug resistance, raising fears of an accidental or intentional leak.

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Published June 18, 2025 in Pathogens, the study was funded by NIH/NIAID grants including 1R01AI134768 and the Centers of Excellence in Influenza Research and Response (CEIRR), contract number 75N93021C00016.

That NIH contract was awarded to principal investigator Dr. Richard Webby of St. Jude Children’s Research Hospital in Memphis, Tennessee, who also serves as Director of the World Health Organization (WHO) Collaborating Centre for Studies on the Ecology of Influenza in Animals and Birds.

The new study was conducted at the University of Missouri’s Department of Veterinary Pathobiology and Center for Influenza and Emerging Infectious Diseases.

“Wild-type bat H17N10 and H18N11 viruses have been successfully generated using reverse genetics,” the researchers wrote, confirming the use of synthetic reconstruction to resurrect novel pathogens never known to infect humans naturally.

The new pathogen creation comes as the NIH continues funding virus enhancement experiments abroad, including a July 2025 Virology Journal paper in which U.S.-backed researchers in China created lab-made influenza viruses using bird, dog, and human pandemic strains—resulting in chimeras that infected human lung cells more efficiently, triggered heightened inflammation, and carried “considerable zoonotic risk.”

Chimeric Gain-of-Function Virus Construction

The team reportedly created chimeric viruses combining six internal genes from bat influenza viruses (H17N10 or H18N11) with surface genes (HA and NA) from a human-infecting H1N1 strain (A/Puerto Rico/8/1934), forming hybrids that replicate efficiently in Madin-Darby canine kidney (MDCK) cells.

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