Positive Correlation Between the Number of Vaccine Doses and Infant Mortality

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    by Sayer Ji, Green Med Info:

    OMNS (Feb 22, 2023) There exists a heated controversy as to whether COVID-19 vaccines and associated boosters are truly “safe and effective.” Health care providers and regulators recommend COVID-19 vaccines to all individuals, despite differences in risk factors of serious disease among various age groups. Even those who have contracted COVID and have recovered from the disease via natural immunity are strongly encouraged to be vaccinated. Various laws and mandates have been drafted that require COVID-19 vaccination of employees. Senate Bill (SB) 866, introduced on the Senate floor on May 12, 2022, was initially drafted to allow children as young as 12-years of age to make their own medical decisions, including the administration of an FDA approved COVID-19 vaccine, without the knowledge or consent of their parents and have their medical records sealed. This measure was subsequently amended, but then moved to an inactive file.

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    According to Dr. E. G. Bailey, a bioinformatics course instructor and her students, vaccine hesitancy “has intensified due to the rapid development and distribution of the COVID-19 vaccine.” They voice concern regarding “anti-vaccine information” being shared on social media, and appear to target for retraction a 2011 peer-reviewed study published in the journal Human and Experimental Toxicology that I coauthored with Neil Miller. In this paper, we reported a counterintuitive correlation demonstrating that among the most highly developed nations, those that require the most vaccines for their infants tend to have the worst infant mortality rates (IMRs) [1]. Bailey and nine coauthors uploaded a preprint manuscript [2] that reports, “it is troublesome that this [the Miller and Goldman] manuscript is in the top 5% of all research outputs since its publication, being shared extensively on social media with tens of thousands of likes and re-shares (see https://acs.altmetric.com/details/406556).”

    If all vaccines were truly “safe and effective,” would not everyone be actively seeking to be vaccinated to gain protection against “vaccine preventable” diseases? Interestingly, many individuals assigned the label “anti-vaccine” initially manifested a “pro-vaccine” mindset. It was only after one or more of their own children experienced an adverse vaccine reaction, or they learned of an adverse reaction from friends, that their perception of vaccines changed. It is not just the lay public that has become skeptical of claims that vaccines have a positive risk-to-benefit ratio. A diverse range of medical professionals and researchers challenge that paradigm as exemplified by Seneff et al. [3] and other emerging peer-reviewed studies that specifically question the-benefit of COVID-19 vaccination and subsequent boosters compared to protection afforded by natural immunity. After a 30-year career, the recent resignation of Dr. Philip R. Krause, former FDA Deputy Chief for Vaccines, likely speaks to his integrity of supporting vaccine safety and estranging himself from an agency whose decision-making has become captured by the pharmaceutical industry and increasing conflicts of interests.

    The Bailey manuscript (Nysetvold et al. [2]), is methodologically flawed by its use of data from both highly developed and Third World nations that have the tendency to attenuate the strength of the correlation between number of vaccine doses and IMR. Their failure to account for differences in nations’ vaccination rates and diversity (heterogeneity) of socio-economic factors, likely explains why they were only able to report a statistically significant positive correlation (r = 0.16, p < .03) that is very weak relative to the stronger correlation, r = 0.70 (p < .0001), reported by Miller and Goldman [1]. Miler and Goldman avoided introducing many confounders by performing linear regression analysis using data from the US (which specified the most vaccine doses of any nation) and the 29 nations with better IMRs than the US. These nations inherently reported high vaccination rates (exceeding 90%) and displayed homogeneity of socio-economic factors.

    Once the critics achieved a “negligible” association, it is likely that outcome reporting biases influenced them to pursue other investigations that they considered as further evidence in support of the “safety and effectiveness” of vaccines [4]. For example, in their analysis of IMR versus percentage vaccination rates for each of 8 vaccines, they report inverse correlations (e.g., as the percentage vaccination rate increases, IMR improves) for 7 vaccines. However, close inspection of the scatter plot reveals that vaccines are not necessary for low IMR (some countries with low IMR have lower dose schedules) nor are they sufficient (some countries with high dose schedules have very high IMR) [5]. Moreover, the methodology used by the critics ignore the possibility of synergistic effects of combinations of vaccines.

    The methodology, results, and conclusions of several analyses that were performed by these critics are critically reviewed in a recent peer-reviewed publication by Goldman and Miller [5] which includes three new analyses (e.g., odds ratio, sensitivity analysis, and 2019 replication) that affirm the positive correlation (of their original study) (Table 1). An odds ratio analysis performed by an independent statistician, Dr. Walter Schumm, split the nations at the median for IMR and for the total number of vaccine doses. Three of eleven control variables that were investigated (i.e., child poverty rate, pertussis vaccination rate, and teenage fertility rate) were statistically significant. None of these variables lowered the correlation below 0.62, thus robustly confirming the original findings [5]. A sensitivity analysis demonstrated that the original study of 30 top nations could have been expanded to sixteen additional nations with IMRs worse than the US (for a total of 46 nations) and the linear regression analysis of IMR and number of vaccine doses would have remained statistically significant. The Miller and Goldman 2011 study using 2009 data was replicated using 2019 data. Linear regression analysis based on the US (which now ranked 44th based on IMR and continued to specify the most vaccine doses of any nation) and the 43 nations with improved IMRs, corroborated the positive correlation between number of vaccine doses and IMR.

     

    Table 1. Multiple analyses by Goldman and Miller affirm a positive correlation between number of vaccine doses and infant mortality rates

    There is credible evidence and biological plausibility for an association between pediatric vaccines and infant deaths. Of the 2605 infant deaths reported to the Vaccine Adverse Event Reporting System (VAERS) from 1990 through 2019, 58% clustered within three days post-vaccination, and 78% occurred within seven days post-vaccination, confirming that infant deaths tend to occur in temporal proximity to vaccine administration [6]. The excess of deaths during these early post-vaccination periods was statistically significant (p < 0.00001). This study, and studies by Aaby et al. [7-9] (who discovered that vaccines have non-specific effects that can increase or decrease mortality from infectious diseases not targeted by the vaccine), provide additional evidence for an association between increased vaccine doses and higher rates of infant mortality.

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