Compound from aged garlic demonstrates anti-cancer activity

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by Michelle Simmons, Natural News:

Researchers from Fujian Normal UniversityShenzhen Third People’s Hospital, and The University of Hong Konglooked at the anti-cancer activity of a compound in aged garlic called S-allylmercaptocysteine (SAMC) in a review of studies. They published their findings in the Chinese Journal of Natural Medicines.

  • Daily consumption of food supplements with anti-cancer potential has become a way to prevent and manage cancer.

  • Emerging evidence supports a link between garlic consumption and decreased cancer incidence.
  • Notably, aged garlic extract (AGE) has stronger anti-cancer activities than that of fresh garlic, because it is enriched with AGE-specific organosulfur compounds, such as SAMC.
  • In this review, the researchers looked at studies on SAMC and its anti-cancer potential.
  • They summarized the up-to-date mechanistic pathways associated with the anti-proliferative, anti-metastatic and pro-apoptotic effects of SAMC in various cancer models.
  • Evidence suggested that SAMC can protect against cancer because of its ability to eliminate reactive oxygen species (ROS) and increase antioxidant enzymes.
  • SAMC also exhibits anti-tumor effects by activating mitogen-activated protein kinase (MAPK), scavenging active oxygen, and inhibiting inflammation.
  • SAMC can induce Bcl-2 family imbalance to cause programmed cell death of tumor cells.
  • It can also inhibit tumor cell proliferation and suppress tumor cell invasiveness.
  • Additionally, it can increase the chemosensitivity of cancer cells.

Based on the evidence gathered, the researchers concluded that SAMC in aged garlic can be used as a promising daily food supplement for preventing and treating cancer.

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