by Evangelyn Rodriguez, Natural News:
In a study published in the Journal of the Science of Food and Agriculture, researchers from India evaluated the seeds of Musa balbisiana Colla. or wild banana – a species native to South Asia – for anti-diabetic potential. They also isolated an active compound called apiforol in the seed extracts, which showed potential as an alpha-glucosidase and glycation inhibitor.
- Phytochemicals were extracted from banana seeds using different solvents.
- The anti-diabetic activity of these chemicals were evaluated based on their ability to inhibit enzymes that break down carbohydrates, prevent glycation, and improve glucose uptake in L6 myoblasts.
- Acetone proved to be the most effective extraction solvent; the acetone extract inhibited glycation as well as alpha-glucosidase and alpha-amylase activity better than the other extracts.
- Apiforol, a phytochemical isolated only from the acetone extract, showed promise as an alpha-glucosidase inhibitor and a glycation inhibitor; it also improved glucose uptake in vitro.
- Molecular docking studies showed the efficient binding of apiforol in the active sites of alpha-glucosidase, which enabled inhibition of enzyme activity.
The results of this study suggested that M. balbisiana may be a good addition to an anti-diabetic diet as it improved glucose uptake and exhibited alpha-glucosidase- and glycation-inhibiting activities.